Serum Angiopoietin-2 and Syndecan-1 as Predictors of Multi-Organ Dysfunction in Sepsis: A Prospective Observational Study

Nityanand Rao Patil; Jai Bharat Bhalke; Patil Archana

doi:10.37022/wjcmpr.v8i3.450

Authors

Nityanand Rao Patil Associate Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital (JIMSH), North Kolkata.
Jai Bharat Bhalke Associate Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital (JIMSH), North Kolkata.
Patil Archana Associate Professor, Department of Pathology, TRR Institute of Medical Sciences (TRR IMS), Inole, Hyderabad.

Abstract

Background: Endothelial injury may contribute to progression of organ dysfunction in sepsis. This study evaluated Angiopoietin-2 and Syndecan-1 as predictors of subsequent multi-organ dysfunction syndrome (MODS).

Methods: In this prospective observational study, 200 adults with sepsis were enrolled within 24 hours of recognition. Patients with established MODS at baseline were excluded. Serum Angiopoietin-2 and Syndecan-1 were measured at enrollment, and participants were followed for development of MODS within 7 days. Logistic regression and ROC analyses were performed.

Results: MODS developed in 73 patients (36.5%). Median Angiopoietin-2 and Syndecan-1 concentrations were significantly higher in the MODS group. Baseline SOFA, lactate, Angiopoietin-2, and Syndecan-1 remained independently associated with MODS. Angiopoietin-2 and Syndecan-1 showed AUCs of 0.766 and 0.784, respectively, while the combined clinical-biomarker model achieved an AUC of 0.859.

Conclusion: Angiopoietin-2 and Syndecan-1 improved early prediction of MODS beyond conventional clinical severity measures.

Keywords:

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DOI

https://doi.org/10.37022/wjcmpr.v8i3.450

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