Recent advances on novel periodontal drug delivery system
Abstract
Periodontitis is an infectious disease resulting in inflammation the supporting within tissues of the teeth, progressive attachment loss and bone loss-carranza. Some of the etiology and risk factors are Microbial factors, local factors, systemic factors, genetic factors and behaviour factors. Periodontitis can occur at any age, most frequently observe in adults at the age of 30-35years. It involves the degeneration of periodontal ligaments, resorption of alveolar bone resulting in the disruption of the structure of the teeth. In global population nearly 10-15% of people are suffering with severe periodontitis according to WHO. In management of periodontal infection Antibacterial agents are most widely used. Widening of PDL space, generalised loss of alveolar bone are the radiographic feature. Treatment requires more aggressive surgical care. Because of abundant source, lack of toxicity and high tissue compatibility the Biodegradable polymers are extensively employed in periodontal drug delivery devices. In the last decades, the treatment has been optimized for the use of drug delivery systems to the periodontal pocket, with the advantage of delivering the drug in the specific site, sustaining and/or controlling the drug concentration. Recently, the use of new drug delivery systems has been receiving great interest. This review approaches the main delivery systems for the administration of drugs to the periodontal pocket, their usefulness as well as the advancement of these systems effectiveness in the periodontal therapy.
Keywords:
Periodontal diseases, Periodontal pocket, Delivery systems, periodontal pocket deliveryDOI
https://doi.org/10.37022/wjcmpr.v4i2.210References
1. Abu Fanas S, Drucker D, Hull, P. (1991). Evaluation of acrylic strips containing amoxycillin with clavulanic acid for local drug delivery.
2. J Dent 19:92–6. Addy M, Hassan H, Moran J, et al. (1988). Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease: a three month follow-up study. J Periodontol 59:557–64. Agarwal E, Pradeep A, Bajaj P, Naik SB. (2012). Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. J Periodontol 83: 1155–63.
3. Ahuja A, Ali J, Rahman S. (2006a). Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterisation. Die Pharmazie Int J Pharm Sci 61:25–9. Ahuja A, Ali J, Sarkar R, et al. (2003). Targeted retentive device for orodental infections: formulation and development. Int J Pharm 259: 47–55.
4. Ahuja A, Ali J, Shareef A, Khar R. (2006b). Formulation and development of targeted retentive device for the treatment of periodontal infections with amoxycillin trihydrate. Indian J Pharm Sci 68:442–47.
5. Ahuja A, Baiju C, Ahuja V. (2012). Role of antibiotics in generalized aggressive periodontitis: a review of clinical trials in humans. J Indian Soc Periodontol 16:317–23. Aishwarya S, Mahalakshmi S, Sehgal PK. (2008). Collagen-coated polycaprolactone microparticles as a controlled drug delivery system. J Microencap 25:298–306.
6. Bako´ J, Szepesi M, Ma´rton I, et al. (2007). Synthesis of nanoparticles for dental drug delivery systems. Fogorvosi Szemle 100:109–13. Bako´ J, Vecsernye´s M, Ujhelyi Z, et al. (2013).
7. Composition and characterization of in situ usable light cured dental drug delivery hydrogel system.
8. J Mater Sci Mater Med 24:659–66. Bansal K, Rawat M, Jain A, et al. (2009). Development of satranidazole mucoadhesive gel for the treatment of periodontitis. AAPS Pharmscitech 10:716–23. Bergstro¨m J. (1989). Cigarette smoking as risk factor in chronic periodontal disease. Comm Dent Oral Epidemiol 17:245–7.
9. Bottino MC, Arthur RA, Waeiss RA, et al. (2014). Biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. Clin Oral Investig. [Epub ahead of print].
10. Bako´ J, Szepesi M, Ma´rton I, et al. (2007). Synthesis of nanoparticles for dental drug delivery systems. Fogorvosi Szemle 100:109–13. Bako´ J, Vecsernye´s M, Ujhelyi Z, et al. (2013). Composition and characterization of in situ usable light cured dental drug delivery hydrogel system.
11. J Mater Sci Mater Med 24:659–66. Bansal K, Rawat M, Jain A, et al. (2009). Development of satranidazole mucoadhesive gel for the treatment of periodontitis. AAPS Pharmscitech 10:716–23. Bergstro¨m J. (1989). Cigarette smoking as risk factor in chronic periodontal disease. Comm Dent Oral Epidemiol 17:245–7. Bottino MC, Arthur RA, Waeiss RA, et al. (2014).
12. Deasy P, Collins AE, Maccarthy DJ, Russell R. (1989). Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease. J Pharm Pharmacol 41: 694–9.
13. Dhadse P, Gattani D, Mishra R. (2010). The link between periodontal disease and cardiovascular disease: how far we have come in last two decades? J Indian Soc Periodontol 14:148–54. Di L, Pi-Shan Y, Deyu H, Fuxiang L. (2013).
14. Minocycline hydrochloride liposome controlled-release gel improves rat experimental periodontitis. West China J Stomatol 31:592–6. Di Turi G, Riggio C, Vittorio O, et al. (2011). Sub-micrometric liposomes as drug delivery systems in the treatment of periodontitis. Int J Immunopathol Pharmacol 25:657–70.
15. Deasy P, Collins AE, Maccarthy DJ, Russell R. (1989). Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease. J Pharm Pharmacol 41: 694–9.
16. Dhadse P, Gattani D, Mishra R. (2010). The link between periodontal disease and cardiovascular disease: how far we have come in last two decades? J Indian Soc Periodontol 14:148–54. Di L, Pi-Shan Y, Deyu H, Fuxiang L. (2013). Minocycline hydrochloride liposome controlled-release gel improves rat experimental periodontitis. West China J Stomatol 31:592–6. Di Turi G, Riggio C, Vittorio O, et al. (2011). Sub-micrometric liposomes as drug delivery systems in the treatment of periodontitis. Int J Immunopathol Pharmacol 25:657–70.
17. Singh K, Arora N, Garg T. (2012a). RFID: a trustable security tool in pharmaceutical industry. Am J Pharm Tech Res 2:113–27. Singh K, Arora N, Garg T. (2012b).
18. Superbug: antimicrobial resistance due to NDM-1. Int J Institutional Pharmacy Life Sci 2:58–66. Singh O, Garg T, Rath G, Goyal AK. (2014b). Microbicides for the treatment of sexually transmitted HIV infections. J Pharm 1–18.
19. Tiwari G, Tiwari R, Rai AK. (2010). Studies on development of controlled delivery of combination drug (S) to periodontal pocket. Indian J Dent Res 21:72–83. Tonetti M, Cugini M, Goodson J. (1990).
20. Bhabani Shankar Nayak, Jharana Dash, Suprava Sethy, P. Ellaiah, and Suroj Sahoo. “Formulation Design and in Vitro Characterization of Clotrimazole Dental Implant for Periodontal Diseases”. International Journal of Pharmaceutics and Drug Analysis, vol. 3, no. 2, Feb. 2015, pp. 68-75, https://www.ijpda.com/index.php/journal/article/view/135.
21. Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers. J Periodont Res 25:243–9. Van Dyke TE, Dave S. (2005). Risk factors for periodontitis. J Int Acad Periodontol 7:3–7.
22. Zamani M, Morshed M, Varshosaz J, Jannesari M. (2010). Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases. Int Dent Rev 75: 179–85.
23. Zhang S, Huang Y, Yang X, et al. (2009). Gelatin nanofibrous membrane fabricated by electrospinning of aqueous gelatin solution for guided tissue regeneration. J Biomed Mater Res A 90:671–9.
2. J Dent 19:92–6. Addy M, Hassan H, Moran J, et al. (1988). Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease: a three month follow-up study. J Periodontol 59:557–64. Agarwal E, Pradeep A, Bajaj P, Naik SB. (2012). Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. J Periodontol 83: 1155–63.
3. Ahuja A, Ali J, Rahman S. (2006a). Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterisation. Die Pharmazie Int J Pharm Sci 61:25–9. Ahuja A, Ali J, Sarkar R, et al. (2003). Targeted retentive device for orodental infections: formulation and development. Int J Pharm 259: 47–55.
4. Ahuja A, Ali J, Shareef A, Khar R. (2006b). Formulation and development of targeted retentive device for the treatment of periodontal infections with amoxycillin trihydrate. Indian J Pharm Sci 68:442–47.
5. Ahuja A, Baiju C, Ahuja V. (2012). Role of antibiotics in generalized aggressive periodontitis: a review of clinical trials in humans. J Indian Soc Periodontol 16:317–23. Aishwarya S, Mahalakshmi S, Sehgal PK. (2008). Collagen-coated polycaprolactone microparticles as a controlled drug delivery system. J Microencap 25:298–306.
6. Bako´ J, Szepesi M, Ma´rton I, et al. (2007). Synthesis of nanoparticles for dental drug delivery systems. Fogorvosi Szemle 100:109–13. Bako´ J, Vecsernye´s M, Ujhelyi Z, et al. (2013).
7. Composition and characterization of in situ usable light cured dental drug delivery hydrogel system.
8. J Mater Sci Mater Med 24:659–66. Bansal K, Rawat M, Jain A, et al. (2009). Development of satranidazole mucoadhesive gel for the treatment of periodontitis. AAPS Pharmscitech 10:716–23. Bergstro¨m J. (1989). Cigarette smoking as risk factor in chronic periodontal disease. Comm Dent Oral Epidemiol 17:245–7.
9. Bottino MC, Arthur RA, Waeiss RA, et al. (2014). Biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. Clin Oral Investig. [Epub ahead of print].
10. Bako´ J, Szepesi M, Ma´rton I, et al. (2007). Synthesis of nanoparticles for dental drug delivery systems. Fogorvosi Szemle 100:109–13. Bako´ J, Vecsernye´s M, Ujhelyi Z, et al. (2013). Composition and characterization of in situ usable light cured dental drug delivery hydrogel system.
11. J Mater Sci Mater Med 24:659–66. Bansal K, Rawat M, Jain A, et al. (2009). Development of satranidazole mucoadhesive gel for the treatment of periodontitis. AAPS Pharmscitech 10:716–23. Bergstro¨m J. (1989). Cigarette smoking as risk factor in chronic periodontal disease. Comm Dent Oral Epidemiol 17:245–7. Bottino MC, Arthur RA, Waeiss RA, et al. (2014).
12. Deasy P, Collins AE, Maccarthy DJ, Russell R. (1989). Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease. J Pharm Pharmacol 41: 694–9.
13. Dhadse P, Gattani D, Mishra R. (2010). The link between periodontal disease and cardiovascular disease: how far we have come in last two decades? J Indian Soc Periodontol 14:148–54. Di L, Pi-Shan Y, Deyu H, Fuxiang L. (2013).
14. Minocycline hydrochloride liposome controlled-release gel improves rat experimental periodontitis. West China J Stomatol 31:592–6. Di Turi G, Riggio C, Vittorio O, et al. (2011). Sub-micrometric liposomes as drug delivery systems in the treatment of periodontitis. Int J Immunopathol Pharmacol 25:657–70.
15. Deasy P, Collins AE, Maccarthy DJ, Russell R. (1989). Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease. J Pharm Pharmacol 41: 694–9.
16. Dhadse P, Gattani D, Mishra R. (2010). The link between periodontal disease and cardiovascular disease: how far we have come in last two decades? J Indian Soc Periodontol 14:148–54. Di L, Pi-Shan Y, Deyu H, Fuxiang L. (2013). Minocycline hydrochloride liposome controlled-release gel improves rat experimental periodontitis. West China J Stomatol 31:592–6. Di Turi G, Riggio C, Vittorio O, et al. (2011). Sub-micrometric liposomes as drug delivery systems in the treatment of periodontitis. Int J Immunopathol Pharmacol 25:657–70.
17. Singh K, Arora N, Garg T. (2012a). RFID: a trustable security tool in pharmaceutical industry. Am J Pharm Tech Res 2:113–27. Singh K, Arora N, Garg T. (2012b).
18. Superbug: antimicrobial resistance due to NDM-1. Int J Institutional Pharmacy Life Sci 2:58–66. Singh O, Garg T, Rath G, Goyal AK. (2014b). Microbicides for the treatment of sexually transmitted HIV infections. J Pharm 1–18.
19. Tiwari G, Tiwari R, Rai AK. (2010). Studies on development of controlled delivery of combination drug (S) to periodontal pocket. Indian J Dent Res 21:72–83. Tonetti M, Cugini M, Goodson J. (1990).
20. Bhabani Shankar Nayak, Jharana Dash, Suprava Sethy, P. Ellaiah, and Suroj Sahoo. “Formulation Design and in Vitro Characterization of Clotrimazole Dental Implant for Periodontal Diseases”. International Journal of Pharmaceutics and Drug Analysis, vol. 3, no. 2, Feb. 2015, pp. 68-75, https://www.ijpda.com/index.php/journal/article/view/135.
21. Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers. J Periodont Res 25:243–9. Van Dyke TE, Dave S. (2005). Risk factors for periodontitis. J Int Acad Periodontol 7:3–7.
22. Zamani M, Morshed M, Varshosaz J, Jannesari M. (2010). Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases. Int Dent Rev 75: 179–85.
23. Zhang S, Huang Y, Yang X, et al. (2009). Gelatin nanofibrous membrane fabricated by electrospinning of aqueous gelatin solution for guided tissue regeneration. J Biomed Mater Res A 90:671–9.
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2022-04-28
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Recent advances on novel periodontal drug delivery system. World Journal of Current Med and Pharm Research [Internet]. 2022 Apr. 28 [cited 2026 Jan. 27];4(2):18-22. Available from: https://www.wjcmpr.org/index.php/journal/article/view/210
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How to Cite
1.
Recent advances on novel periodontal drug delivery system. World Journal of Current Med and Pharm Research [Internet]. 2022 Apr. 28 [cited 2026 Jan. 27];4(2):18-22. Available from: https://www.wjcmpr.org/index.php/journal/article/view/210
